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The pharmacokinetics of alfentanil, 300 I~g" kg -I IV, were determined in patients undergoing elective abdominal aortic reconstruction. The mean age ( • SD)

(Group Prop; n = 14) and the other isoflurane/alfentanil (Group [so; n = 13) . Periods of haemodynamic instability were correlated to episodes of myocardial ischaemia as assessed by Holter monitoring (begun the evening before surgery and ceasing the morning 9.t" the first postoperative day). In Group Prop, anaesthesia was induced with alfentanil 30 #g" kg -z iv, propofol up to L5 rag" kg -t and vecuronium 0.15 mg" kg -z, and maintained with infusions of propofol at 3-12 mg" kg -t" hr -1 and alfen-