In the present study, titanomagnetite nanoparticles (Fe 3-x Ti x O 4 NPs) were synthesized via coprecipitation approach and then functionalized using 3trimethoxysilylpropyl chloride silan coupling agent followed by tetrabutylammonium asparaginate through a facial and newly one-pot procedure to afford an ionic liquid (IL)-modified Fe 3-x Ti x O 4 NPs. The synthesized NPs were examined as potent and recyclable nanocatalysts for one-pot three-component synthesis of 2,3-dihydroquinazolin-4(1H)-ones under solvent-free conditions. Easy magnetic separation and efficient recyclability of the catalyst, excellent yields of the reactions, low reaction times as well as solvent-free conditions are the most important advantages of the present procedure that qualified the fabricated Fe 3-x Ti x O 4 NPs as a nanocatalyst for industrial applications.