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Spinal cord injury (SCI) is a neuro-destruction occurred from a complete or incomplete, traumatic or non-traumatic that results in degeneration, structural, biochemical, and physiological changes of tissue. SCI is a clinical problem associated with impairments in different aspects of the patient's life. The pathophysiology of SCI involves a primary phase that directly disrupts axons, cell membranes, and blood vessels. This primary phase is followed by a secondary phase involving vascular dysfunction, ischemia, excitotoxicity, oxidative stress, inflammation, and cell death. If this second phase isn't managed, it will result in many pathological processes that will cause several clinical complications. The aim of rehabilitation and other treatments is to enhance the functional level and to reduce secondary morbidity as well as improve the quality of health of the patient. SCI results in different complications in different organs of the individual. Early diagnosis, treatment, and prevention of complications in SCI patients are very important for limiting these complications. This review was carried out in order review the data about clinical complications associated with SCI, including multiple organ dysfunction, systemic inflammation, immune suppression, neurogenic shock, autonomic dysreflexia, orthostatic hypotension, temperature regulation, sweat secretion, respiratory complications and dysphagia, thromboembolism, urinary system, reproductive system, skeletal muscle, bone, liver, spleen and gastrointestinal tract. The purpose of this narrative review is to provide knowledge on the SCI complications, sign and symptoms, risk factors prevention and treatment of complications caused by SCI.

COVID-19 is a contagious disease that attacks many organs but the lungs are the main organs affected. The inflammasome activation results in the exacerbation of inflammatory response in infectious disease. The aim of this study is to investigate the formation and activity of the NLRP3 inflammasome complex and the histopathological changes caused by the coronavirus in the lung of deceased persons with COVID-19. In total, 10 corpses; 5 corpses with no history of any infectious diseases and COVID-19 and 5 corpses with the cause of death of COVID-19 were included in this study. Lung tissue samples were harvested during autopsy under safe conditions. Fresh tissues in each group were used to measure the genes expression and proteins level of NLRP3, ASC, Caspase-1, IL-1β, IL-6 and TNF-α and a routine hematoxylin and eosin staining was performed for histological assessment. Data are represented as the means ± SD. Statistical significance difference was accepted at a p-value less than 5%. The NLRP3, ASC, Caspase-1, IL-1β, IL-6 and TNF-α genes expression and proteins level were elevated in the lung of the COVID-19 group in comparison with the control group. Histological findings presented the increasing number of polymorphonuclear leukocytes, macrophages and also pulmonary fibrosis in the lungs of corpses with the cause of death of COVID-19. High expression of NLRP3 inflammasome components and its relation with the pathophysiology of the coronavirus-infected lung suggested that targeting the NLRP3 inflammasome could be helpful in achieving a more effective treatment in patients with COVID-19.