A patient with CML is presented in whom Gaucher’s cells were seen in the bone marrow and other tissues. Biochemical and electron microscopic studies established the similarity of these cells to those found in Gaucher’s disease. Evidence is presented which indicates that the granulocyte is normally the major source of sphingolipid and that the Gaucher’s cells seen in CML arise from excessive granulocyte turnover.
a lower level of circulating androgen in hyperthyroid rats.Summary. Maintenance of elevated levels of thyroxine in rats from birth to 36 days of age accelerates the maturation of the seminiferous epithelium of the testis of the rat but a t the same time reduces the rate of increase in weight of the testes and the ventral prostate gland.
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