Introduction: Diabetic foot ulcer is among the commonest complications of diabetic mellitus, attributing to a significant number of morbidity and mortality in diabetic patients, and enormous economic loss to the families and the country. Nowadays, the incidence of diabetic foot ulcer is increasing due to the increased prevalence of diabetes, prolonged life expectancy of diabetic patients and lifestyle change. Ethiopia is one of the top five countries with the largest number of people affected by DM in sub-Saharan Africa.Objective: To assess patients' knowledge, attitudes, and practices towards prevention of diabetic foot ulcer among adult diabetic patients attending at follow-up clinic of