This study was carried out during 2017 and 2018 seasons to study the effect of boric acid, Magnesium sulphate and some amino acids (Tryptophan, Methionine and Arginine) at 0.05%, 0.2% and 0.1% respectively, either alone or combination on solving clusters looseness, shot berries and coloration problems in Roomy Red grapevines grown under Minia region. Vegetative growth, vine nutritional status, berry setting %, yield, cluster weight as well as physical and chemical characteristics of the berries were positively affected by using amino acids, magnesium sulphate and boric acid either as a single or in combinations when compared to the check treatment. Also, shot berries % and total acidity reduced greatly with application of such treatments. Using boric acid, magnesium sulphate and amino acids influenced positively the studied characters in ascending order. Combined applications showed more effects rather than single ones in this respect. Three sprays of a mixture containing boric acid, Magnesium sulphate and some amino acids (Tryptophan, Methionine and Arginine) at 0.05%, 0.2% and 0.1%, respectively, was responsible for obtaining higher yield, lower shot berries and clusters looseness as well as promoting berries quality of Roomy Red grapevines.