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Fourteen different substances were evaluated for their usefulness in reducing surf ace defects , heat due to friction and energy consumption in an instrumented extruder.The materials include several common lubricants and glidants, surface active agents, humectants, polyethylene glycol and a binder in a simple binary system with high drug loading. The substances under study were evaluated at two concentrations in a matrix composed of acetaminophen, Avicel PH-101 (70:30) and water. Maximum screen temperature, peak amperage draw, surface morphology of the extrudate, resistance to 944 MESIHA AND VALLES applied force, resistance to abrasion, surface morphology of the spheres, sphericity and size analysis were determined for each substance/concentration combination. High HLB surfactants, particularly SLS, performed best at levels as low as 0.125%, keeping heat and amperage draw to a minimum and greatly reducing surface defects.

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