Deuterated organic molecules are of utmost importance in many areas of science and have been recently intensively investigated in medicinal chemistry due to their enhanced metabolic stability. The development of...

Ynamides provide unique opportunities not only for the introduction of nitrogen‐containing motifs into organic molecules but also for the generation of otherwise hardly accessible highly reactive intermediates. This addendum discusses the synthesis of ynamides with copper as the general solution. It provides information on 1,1‐dibromo‐1‐alkenes as practical alkynylating agents. The addendum also discusses the chemistry of ynamides, which is a versatile and useful building blocks in organic synthesis. The development of efficient synthetic procedures for the preparation of ynamides, including those from 1,1‐dibromo‐1‐alkenes, paved the way for their use as building blocks in organic chemistry. Besides the use of strong acids, electrophilic metal complexes have also proven successful to activate ynamides.