Lipophilic drugs comprise of majority of the active pharmaceutical ingredients which shows the lower oral bioavailability. Many methods have been used to enhance the bioavailability, especially the lipid-based formulations have gained a lot of attention of the researchers, one among the lipid-based formulation approach is the self-emulsifying drug delivery system (SEDDS). SEDDS basically is an isotropic mixture of oils, surfactants and co-surfactants or co-solvents, which after reaching the gastro intestinal tract (GIT) emulsifies itself to emulsion upon mild agitation in the stomach. Solid self-emulsifying drug delivery system (S-SEDDS) is one of advancements in the self-emulsifying systems, which uses the adsorbents where the liquid self-emulsifying system adsorbs and converts itself in to solid, which overcomes the disadvantages of the liquid SEDDS. Various S-SEDDS have been developed in recent years and few of them are, tablets, pellets, microbeads, suppositories, nanoparticles, patches, microspheres etc, without any compromise in the drug release kinetics. These formulations are the cost-effective means of enhancing the bioavailability of the lipophilic drugs.