Gene transfer is a new treatment modality that introduce new genes into cancerous cell or surrounding the tissue to cause cell death or slow the growth of cancer.Gene therapy is treatment that become important in preventing deaths from cancer. It is intensely used in research projects in 1989. First commercial gene treatment in 2003 was for neoplasia. Some examples of cancer that are treated with gene therapy are Brain cancer, Lung cancer, Breast cancer, Pancreatic cancer, Liver cancer, Bladder, Head and neck, Skin, Ovarian cancers etc. There are different gene therapy strategies for cancer Such as pro-drug activation suicide gene therapy, Anti-angiogenic gene therapy, Oncolytic viro-therapy, Immunotherapy, Gene therapy-based immune modulation.