The aim of the present study is to evaluate the thrombolytic activity of aqueous and ethanol extracts of Clerodendrum phlomidis roots. The activity was assessed by thrombolytic assay (clot lysis) using streptokinase as standard. The preliminary phytochemical screening revealed the presence of carbohydrates, glycosides, phenolic compounds like tannins and flavonoids. Aqueous and ethanol extracts showed 48.53 % and 30.13 % clot lysis respectively while the standard (streptokinase) showed 50.74 % clot lysis. Aqueous extract at 20 mg/ml dose level showed significant (***P < 0.001) clot lysis when compared to control. The result indicates that aqueous extract has better thrombolytic activity compared to ethanol extract.