Currently, the mining industry in Tanzania faces significant challenges including the presence of radionuclides in the working environment. In this work, different indices were applied to assess the health risk of people living and working in the study area. The radiation hazards in the studied mining areas are compared with the recommended local and international guidelines. The health risk and mitigation measures due to radioactive elements exposure to mine workers and people dwelling in the mines is established. The hyper pure germanium detector (HPGe) was used for radioactivity analysis. The radon gas levels were measured using the Alpha Guard radon monitor. The results on radioactivity; mean effective dose; annual gonadal equivalent and absorbed dose; radium equivalent; internal and external hazard indices; alpha and gamma indices; and the radon gas revealed high values in mining areas compared to the control area. However, some of the levels of radionuclides along with their hazard indices are lower than the recommended international limits. The mitigation measures which include dust suppression using water spray and the use protection gears such as masks and gloves are recommended. The present study recommends follow up and further studies in the ASGM subsector.