Background: The newly emerged pandemic has created many dilemmas in dental clinical practice all over the world. Most of the practicing dentists and dental students are at higher risk of getting infected and transmitted the disease. The study aimed to explore the knowledge and attitudes among dental interns in Saudi Arabia related to the COVID-19 pandemic. Materials and Methods: An online questionnaire survey was carried out among dental students pursuing their internship at different universities in Saudi Arabia. A combination of convenience and snowball sampling was used to identify interns from each province of the Kingdom. The questionnaire was validated and pretested, which recorded the knowledge, attitude, and concerns related to dental practice and COVID-19. Results: The knowledge related to COVID-19 and its importance in clinical dental practice was below average among dental interns, and only 22.2% gave a correct response to all questions. About 80.8% and 85% of the dental students were worried about contracting the infection during dental practice and transmitting it to family and friends, respectively. Conclusion: Dental students showed satisfactory knowledge, attitude, and practices related to COVID-19, and most of them were aware and adhering to the preventive guidelines set by the ministry of health.

Regenerative therapy has been introduced in the literature for a long time and is currently being practiced in different fields, including dentistry and endodontics. Many applications have been reported in the literature for stem cell therapy. However, many complications and adverse events were reported in this context. The present literature review sheds more light on the clinical applications of stem cell therapy in regenerative endodontics and the future perspectives in this field. There are no doubts that there are many questions to be answered despite the huge advances in this field. In response to tissue injury, it has been shown that stem cell therapy can strengthen the efficacy of physiological response to these events and improve tissue regeneration. They can be used for managing cases of reversible pulpitis. Moreover, evidence indicates that they can enhance the revascularization of necrotic pulp tissues. Accordingly, these outcomes can significantly change the perspectives of clinical endodontic practice, and current root canal management modalities and perhaps draws researchers into discovering further future applications for other currently untreatable conditions. However, further future investigations are still needed to understand more about the mechanisms of these modalities and improve their clinical applicability.