Background: Applying hydrogel as a topical dressing in modern wound care which will help the autolysis debridement process, so that patients feel comfortable in the wound care process. Objectives: To Knowing the description of Wound Healing in Diabetic Ulcer Patients before and after Hydrogell Administration. Methods: Pre-test and post-test research was used in a quasi-experimental research design. Before measuring the wound, the first activity in the follow-up of this study was giving a pre-test. A final post-test was administered following the hydrogel administration procedure to compare the wound before and after treatment. Results: After the statistical test was carried out, the p-value = 0.000 (p-value <0.05), and the t result was 22.477. This shows the effect of Hydrogell as an autolytic debridement medium on wound healing in diabetic ulcer patients. Which means H0 is rejected and Ha is accepted. Conclusion: Based on the results of research conducted that there is effectiveness of Hydrogell for autolysis debridement in the wound healing process in diabetic ulcer patients.