Efficient regulation of cellular processes is essential for both endogenous and synthetic biological processes. The design of biomolecular feedback controllers that achieve robust and timely regulation is the subject of considerable research at the interface between synthetic biology and control theory. Integral feedback controllers, known for their ability to confer the property of Robust Perfect Adaptation (RPA), are increasingly becoming common features in biological control design. Antithetic integral feedback (AIF) controllers, in particular, have enabled effective chemical reaction realizations of integral controllers that deliver RPA in both deterministic and stochastic settings. This paved the way to experimental implementations of integral controllers in bacterial and mammalian cells. While AIF controllers deliver favorable adaptation properties, they do not necessarily lead to good transient performance or noise reduction properties and may in some cases lead to increased overshoot or cell-to-cell variability. These limitations are commonly circumvented by augmenting new circuitry that realize proportional or derivative feedback mechanisms to enhance dynamic and noise rejection features without affecting the AIF controller's adaptation properties. In this paper, we report that a sensor-based variant of the basic AIF motif exhibits favorable transient dynamic properties and (as reported elsewhere) reduced noise variance. We show that these features are attributed to a "hidden" proportional feedback component that is inherent in the controller structure and that such mechanism is solely responsible for the controller's underlying enhanced dynamic performance and noise rejection properties. This sensor-based AIF controller hence offers a minimal biomolecular realization of Proportional-Integral (PI) control, whereby both integral and proportional feedback mechanisms are achieved through a single actuation reaction.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.