An easy and convenient method is reported for the synthesis of 2-hydroxybenzaldehyde and 2-hydroxynaphthalene-1-carbaldehyde from corresponding phenols by Reimer-Tiemann reaction using aqueous ethyl alcohol and avoiding steam/vaccum distillation.

Direct iodination of several reactive aromatic compounds like hydroxy substituted acetophenones and aldehydes with pyridinium iodochloride (PyICl) proceeded smoothly to afford the corresponding aromatic iodides in good to excellent yield. Pyridinium iodochloride has been found to be an efficient solid iodinating reagent with no hazardous effect and it can be handled safely.

Some new 2,3-diaryl-1,3-thiazolidin-4-one derivatives having a 2,6-dichlorophenyl, antipyrine, or 1,2,4-triazole ring at N-3 and variously substituted 3-iodo-or 3-bromo-phenyl rings at C-2 have been synthesized and tested as antibacterial agents. The results of the in vitro tests showed that some of them have effective antibacterial activity.

No abstract

No abstract