Background:The anticancer and antioxidant effects of the aqueous extract of Indigofera aspalathoides on 20-methylcholanthrene (20-MCA) induced fibrosarcoma were investigated in male albino rats.Materials and Methods:The rats were divided into four different groups, each group consisting of six animals. Group I animals were served as normal control, Group II animals were fibrosarcoma-bearing animals after the incubation period, Group III animals were fibrosarcoma-bearing animals, treated with aqueous extract of I. aspalathoides intraperitoneally at a dose of 250 mg/kg b.w. for 30 days and Group IV animals were administered with the aqueous extract of I. aspalathoides alone, at a dose of 250 mg/kg b.w. for 30 days, served as drug control animals. After the experimental period, all the rats were weighed and killed by cervical decapitation. The serum was separated from the blood for analysis. The weights of the liver and the kidneys were noted. The fibrosarcoma was proved by pathological examinations. The liver and kidney tissues were excised and then homogenized in an ice-cold buffer. These tissues were used for biochemical analysis.Results:The activities of antioxidant enzymes, e.g. catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD), in blood serum, liver, and kidney of control and experimental animals, respectively, have been reported.Conclusion: The present observations suggested that the aqueous extract of I. aspalathoides treatment enhanced the recovery from 20-MCA-induced fibrosarcoma due to its antioxidants and antineoplastic properties.

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Aswagandharishtam is classical medicine for diseases pertaining to nervous system and digestive system prepared by a number of plants and plant parts. The present work is to know the types of biomolecules present in it by GC MS analysis. Aswagandharishtam was procured from standard Ayurvedic outlet and was subjected to Gas Chromatography Mass Spectrometry after due processing. The GC MS analysis of Aswagandharishtam has shown some promising molecules like Prostaglandin A2, Cholesterol, Piperine, Gentamicin a, d-Mannose, Eugenol, Pipradrol among others, which have activities similar to that of Aswagadharistham. This is a preliminary report where some clue about the various types of biomolecules present in Aswagandharishtam was obtained. Further work is on to prove the efficacy of this medicine by other parameters.

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