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<p class="Abstract">In the present study, the anti-oxidant and cytotoxic effects of the different solvent extracts of <em>Pogostemon mollis</em> were analysed. The phenolic, tannin and flavonoid contents were highest in the ethyl acetate extract and analogous to the antioxidant activity results. The extracts showed activities similar to the standard antioxidants. The extent to which the extracts protect free radical damage on DNA was evaluated and showed good genoprotective effects. Bacterial cells and fungal spores and hyphae showed visible damages due to the treatment of ethyl acetate extract. Finally in the cytotoxic analysis, IC₅₀ value was calculated based on the absorbance value of different concentrations. It concluded that <em>P. mollis</em> is a prospective candidate for the various therapeutic applications especially its ethyl acetate extract.</p><p> </p>