Herbal remedies for cosmetic and health-promoting purposes are getting more popular in worldwide. The Compositae (Asteraceae) family of plants is currently an important cause of allergic plant contact dermatitis in Europe. A 55-year-old woman presented with erythema, edema and vesiculobullous lesions over her knees caused by Chamomile. Patch testing with chamomile was positive. The patient has been diagnosed as allergic contact dermatitis. We report a first case of contact dermatitis caused by German chamomile from our country.

Cetuximab, is an IgG1 chimeric monoclonal antibody type of epidermal growth factor receptor (EGFR). It is most commonly prescribed for metastatic colorectal cancer, administered alone or in combination with irinotecan-based chemotherapy regimens (Lee et al., 2008;Segaert and Cutsem 2005;Scope et al., 2009). Acneiform eruption is the most common adverse effect with 80% of incidence (Segaert and Cutsem 2005;Lee et al., 2008). We report two cases of severe acneiform eruption induced by cetuximab with metastatic colorectal cancer.

ARTICLE INFO ABSTRACTHypereosinophilic syndrome (HES) is a multi-organ disease (heart, eye, lungs or nervous tissue). The etiology and pathogenesis of HES is still unknown. It is characterized by 1500 eosinophils/µl of eosinophils in peripheral blood observed during at least six months without any evidence for other known causes of eosinophilia. The skin manifestations of the disease were pruritic, erythematous macules, papules, plaques or nodules and rarely urticaria, angioedema, livedo reticularis, eosinophilic cellulitis, cutaneous necrotizing eosinophilic vasculitis, retiform purpura. Among the skin lesions erythroderma is a rare complication of HES and has only been reported in a few cases (Launay et al., 2002, Granjo et al., 2002. We report here a 78-yrs-old man with pruriginous erythroderma leading to the diagnosis of hypereosinophilic syndrome. In dermatological examination erythrodermia and mild desquamation was noticed entire the body surface with bilateral ectropion.