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Two diazine Schiff base ligands, HLa and HLb, derived from thiocarbohydrazide and salicylaldehyde derivatives were synthesized using the microwave-assisted synthesis approach. The confirmation of both ligands was elucidated through physiochemical and spectroscopy techniques as well as single X-ray crystallography diffraction. The analyses showed that the ligands synthesized were formed as azine instead of thiocarbohydrazone based on the missing thione, C=S moiety, throughout FTIR and NMR spectrascopic data. This finding was further concluded by X-ray crystal analysis. The biological properties of these ligands were screened using the disc diffusion method. The result shows that HLb shows significant inhibition towards all of the bacteria tested.

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A series of tetradentate Zn(II) and Ni(II) Schiff base complexes derived from N,N-Bis-(2-hydroxyl-5-methoxybenzaldehyde)-m-phenylenediamine was synthesized using microwave assisted synthesis approach for 5-15 minutes. The confirmation of the ligand as well the respective complexes has been elucidated through physiochemical and spectroscopy analyses. The studies show that two metal ions formed bridges connecting two Schiff base ligands. The nitrogen and oxygen atoms in each ligand served as coordination sites for the metal ions. The Schiff base ligand and complexes were screened for antimicrobial properties using Disc diffusion method against Escherichia coli, Bacillus subtilis, Enterobacter cloacae, and Klebsiella pneumoniae. The screening shows that both Zn(II) and Ni(II) complexes give signif-icant inhibition towards the bacteria tested.

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