This paper investigates the effect of eleven independent variables as subsets of Employee Orientation, Environment and Organizational System, on the overall performance of the IT sector firms, operating in the area of Islamabad, Pakistan. Variables are investigated by targeting a sample of 15 leading IT sector firms. A total of 225 questionnaires were distributed. The Cronbach's Alpha for the questionnaire resulted in a score of 0.8398. Extensive analysis after the application of multiple regression analysis revealed that, there is an overall average level of relationship between the variables considered. IT sector has shown tremendous progress.