BackgroundAccording to the Global Tuberculosis Report 2015, Indonesia ranked as second country in the world with the highest number of pulmonary tuberculosis cases. By 2015, the number of pulmonary TB new cases in Indonesia has increased to 330.910 cases of 2014 where 324.539 cases. DM is one of the most important factors that influence the occurrence worsening TB. Now is known that DM patients have body's immune response disorder thereby facilitating M. tuberculosis infection and causing TB.MethodThis research is cross sectional design. The sample in this research are adult pulmonary TB patients at General Hospital Grade C period October 1, 2013–March 31, 2016 as much as 225 patients.ResultAFB smear results in patients with type 2 DM with smear 3 + was 14 (17.28%), 2 + was 15 (18.52%), 1 + was 15 (18.52%) and negative (−) was 37 (45.68%). AFB smear results in patients without type 2 DM with smear 3 + was 3 (2.08%), 2 + was 6 (4.17%), 1 + was 19 (13.19%), negative (−) was 112 (77.78%) and have no sputum was 4 (2.78%). Number of adult pulmonary TB patients were 225 patients. Of the 225 patients, found 81 patients with type 2 DM and 144 patients without type 2 DM.ConclusionAFB smear positive found more in adult pulmonary TB patients with type 2 DM compared to TB patient without type 2 DM. It also found statistically significant between type 2 DM with the AFB smear results on adult pulmonary TB patients.

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Airway inflammation in patients with chronic obstructive pulmonary disease (COPD) is an amplified response of the normal immune system that occurs as a result of chronic irritation by toxic substances, such as cigarette smoke. This leads to the characteristic pathological changes in the inflammatory cells of COPD patients. ADAM33 has been reported to be involved in the pathogenesis of COPD in East Asia by affecting airway inflammation and other immune responses. The aim of this study was to determine the potential role of ADAM33 (mRNA and soluble levels) as a biomarker of inflammation in COPD patients. This is a case control study using consecutive sampling. The COPD case and control (non-COPD) groups comprised 37 and 29 patients, respectively. We used univariate analysis to assess differences in the parameters between the groups and bivariate analysis to non-parametrically compare these parameters between the two groups. We observed significantly higher mRNA levels of ADAM33 in the COPD patients (10.39 ± 1.76) as compared to that in the non-COPD individuals (6.93 ± 0.39; P < 0.001). The levels of soluble ADAM33 were also significantly higher in the COPD patients (2.188 ± 1.142 ng/ml) compared to the non-COPD individuals (0.487 ± 0.105 ng/ml; P < 0.001). The mRNA and soluble ADAM33 levels were significantly higher in COPD patients compared to those in the parameter-matched non-COPD individuals. Thus, ADAM33 is a potential biomarker and treatment for inflammation in COPD patients.

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Latar belakang: Penyakit Paru Obstruktif Kronik (PPOK) merupakan penyakit tidak menular yang menjadi salah satu masalah kesehatan di Indonesia diperkirakan terdapat 4,8 juta orang dengan prevalensi 56%. Tujuan: tujuan penelitian ini untuk mengetahui hubungan antara hitung jenis leukosit dengan derajat PPOK berdasarkan gejala klinis dan PPOK GOLD 2019 pada pasien PPOK stabil di Rumah Sakit Islam Jakarta Sukapura periode September 2018 – September 2019. Metode: studi ini merupakan penelitian kuantitatif dengan metode deskriptif analitik. Desain penelitian yang digunakan yaitu cross sectional. Teknik pengambilan sampel dalam penelitian ini yaitu teknik total sampling. Jumlah pasien PPOK stabil yang diteliti sebanyak 35 pasien. Penilaian gejala pada pasien PPOK menurut Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) 2019 dapat menggunakan kuesioner yang sudah divalidasi yaitu COPD Assesment Test/CAT dan Modified Medical Research Council/MMRC. Hasil: Hasil pemeriksaan hitung jenis leukosit terbanyak memiliki nilai eosinofil normal, nilai basofil normal, nilai neutrofil meningkat, nilai monosit normal, dan nilai limfosit normal. Kesimpulan: hasil penelitian menunjukkan kecenderungan peningkatan nilai leukosit pada setiap derajat PPOK, namun secara statistik tidak terdapat hubungan yang signifikan antara hitung jenis leukosit dengan derajat PPOK berdasarkan gejala klinis dan GOLD 2019 pada pasien PPOK stabil di RSIJ Sukapura.