The Republic of Indonesia has a goal to create a just and prosperous society as stated in the 1945 Law. To achieve this goal, it is necessary to carry out development activities. One of the unresolved development problems is employment. Therefore, the purpose of this study was to determine the effect of the minimum wage, education level, industry, Gross Regional Domestic Product (GDP) and government spending on employment opportunities in the Special Region of Yogyakarta. The data used is annual data from 2010–2019 and uses the Random Effect Model approach with the Generalized Least Square (GLS) method. The estimation results show that industry and GRDP have a positive and significant effect on job opportunities in the Special Region of Yogyakarta, while the minimum wage, education level, and government expenditure have a negative and insignificant effect on job opportunities in the Special Region of Yogyakarta.