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SUMMARY Bullous pemphigoid is a rare complication of frusemide therapy. We present two patients in whom the link between frusemide and this condition was not recognised early, and continued frusemide therapy resulted in prolonged leg blistering and ulceration. On withdrawing the drug, all lesions in both patients resolved completely. Although uncommon, this frusemide reaction needs to be borne in mind as it can add to the morbidity of elderly patients with heart failure.