After the eruption of Mount Anak Krakatoa, December 22, 2018, which was accompanied by a large landslide into the waters of the Sunda Strait, resulting a tsunami that hit South Coast of Lampung and West of Banten. According [1], 437 peoples were death, 31,942 peoples were injured and 10 peoples were lost due to this disaster. The tsunami impact toward human lives was calculated by using the human instability equation [3] and TUNAMI Two Layer model was applied to simulate the landslide and propagation of tsunami [2]. The simulation results were validated with observations and field measurements data [1]. The result of simulation showed that flow depth of the tsunami reached 0.29-5.83 m with the tsunami velocity about 0.23-7.49 m/s along the shore of Pandeglang Regency. Using Aida Equation for validate simulation results, has K = 0.96733. The results of calculations using the human instability equation show that the value of hazard risk (HR) > 1 because all critical velocity values lower than velocity of simulation. So, it was mean that tsunami waves occurred in Banten especially Pandeglang Regency has high risk impact for the balance of the human body and this condition related with the observation condition that show many victims included people died and injured in this area.