Cognitive Radio (CR) is an emerging technology to exploit the existing spectrum dynamically. It can intelligently access the vacant spectrum frequency bands. Although a number of methodologies have been suggested for improving the performance of CR networks, little attention has been given to efficient usage, management and energy efficiency. In this paper, a modern paradigm pertaining to the spectrum allotment and usage, manifested as CR, has been introduced as a potential solution to this problem, where the CR (unlicensed) users can opportunistically deploy the available free licensed spectrum bands in such a way that restricts the degree of interference to the extent that the primary (licensed) users can allow. In this article, we analysis and compare various protocols, in addition, we evaluate CREAM MAC, RMC MAC, SWITCH MAC, EECR MAC protocols related to the CR MAC in term of different parameters such as throughput, data transmission and time efficiency. We conclude the most efficient protocol, which have similar features named as Proposed Efficient Cognitive Radio MAC (PECR-MAC) protocol.