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Background: Bladder cancer (BC) one of the most common urologic cancer characterized by the highest recurrence rate, many types belong to BC, but most common of them worldwide are transitional cell carcinoma(TCC) which constitute about 90-95% cases, squamous cell carcinoma (SCC) and adenocarcinomas Objective: This study was designed to evaluate parameters of humoral immunity in Non-muscle invasive (superficial or early) bladder cancer patients in Iraq that may provide a new insight into the future of immunotherapies development and BC management. Materials and methods: Fifty-nine volunteer's patients ranged from 24 to 83years old, and 30 control individuals ranged from 51-80 years old, who attended and admitted to Hospital of Gazi AL-Harery in medical city of Baghdad, and Al-Emamain Al-Khadhemain Teaching hospital was recruited in this investigation. The sera of study groups were subjected to serological test to estimate the levels of (IgA, IgG, IgM and C3) by Single radial immunodiffusion (sRID) assay and Enzyme-Linked immunosorbent assay (ELISA) was used to estimate the serum levels of IL-10. Results: The ages ranged from 24 to 83years (females: 26 to 72years, males: 38 to 83years) with male to female ratio 4.9:1 and ages of controls ranged from 51 to 80years (females: 54 to 70years, males: 51 to 80years) with male to female ratio 2.75:1, the mean ages of cases and controls groups were (61.65±11.04) , current study showed significance dropping in C3 levels in patients control and Mitomycin C groups compared with apparently healthy, levels of IgM showed significant elevation in BCG group compared with apparently healthy group while patients control and mitomycin C groups showed insignificant elevation of IgM. Levels of IgG showed significant elevation in patients control and mitomycin C groups compared with apparently healthy group while in BCG group showed no differences. Serum levels of IL-10 showed no differences between apparently healthy group and each of patient's groups, also showed no differences within patient's groups Conclusions:Bladder cancer is a common urologic malignancy in male than female patients enrolled in this study. Intravesical BCG or Mitomycin C leading to effective anti-bladder cancer immunity in the majority of Patients Humoral immune factor changes in group of patients with Non-muscle Muhammed A. H. Aldabagh invasive bladder cancer treated with intravesical therapy.

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The aim: To distinguish the function role of IL-6 protein levels as well as IL-6 (-174) gene polymorphism in diabetes mellitus patients. Materials and methods: in present case-control study160 (cases 86, control 74) volunteers were enrolled in this study 2.5 ml were added to EDTA tube for molecular investigation IL6 (-174), and other 2.5 ml use for measurement of fasted glucose by spectrophotometry and insulin levels as well as IL-6 level by ELISA. Results: Regarding IL-6-174 (rs1800795), results revealed significant difference at genotype CC (p- value 0.05 with odds ratio 3.49) and allele frequency C (p-value 0.02 with odds 2.17), also at protein level the IL-6 showed significant difference between IL-6 levels and T2DM especial in insulin resistance (IR) group (p-value 0.03) compared with control one (Cont). Conclusions: There is potent relation between IL-6 levels with T2DM and IR groups. There is potent relationship between CC variation of IL-6 (-174) and risk of each T2DM and IR condition.