Objective: To evaluate the implementation of screening colonoscopy amongst first-degree relatives (FDRs) of patients with colorectal cancer (CRC) in Turkey. Materials and Methods: A total of 400 first-degree relatives (mean(SD)age: 42.5(12.7) years, 55.5% were male) of 136 CRC patients were included in this cross-sectional questionnaire based survey. Data on demographic characteristics, relationship to patient and family history for malignancy other than the index case were evaluated in the FDRs of patients as were the data on knowledge about and characteristics related to the implementation of screening colonoscopy using a standardized questionnaire form.

Aerococcus urinae (A. urinae) is an unusual urinary tract pathogen [1][2][3], which is also reported in case of endocarditis [1,[3][4][5], septicemia [6][7][8][9], balanitis and phlegmon [1], lymphadenitis [10], and spondylodiscitis [11] in elderly patients with local or systemic predisposing conditions such as neutropenia and prostatic diseases. A. urinae is a grampositive, catalase-negative, microaerophilic, alpha-hemolytic coccus, growing predominately in tetrads and clusters. A. urinae is usually susceptible to b-lactam antibiotics and resistant to sulfonamides and aminoglycosides. Susceptibility to trimethoprim and cotrimoxazole is variable [9].This paper presents three case reports of the serious A. urinae infections, two associated with bacteremia and to our knowledge the first case recorded of spontaneous bacterial peritonitis (SBP). Case 1A 67-year-old male with preexisting chronic liver disease [due to hepatitis C virus (HCV) infection] was admitted to the hospital with a history of fever, abdominal pain, nausea, and vomiting. On admission, he had a temperature of 37.8°C, diffuse ascites, abdominal distention and splenomegaly. The other physical examinations were normal. The laboratory results were as follows: peripheral white blood count 15,800 mm -1 , hemoglobin level 11.3 g/dl, hematocrit 33.5%, and C-reactive protein (CRP) 18 mg/l. Abnormal biochemical findings were as follows; alanine aminotransferase 52 IU/l, aspartate aminotransferase 121 IU/l, c-glutamyl transpeptidase 78 IU/l, albumin 2.7 g/dl, and the protrombin time 14.6 s. Ascitic fluid findings were as follows; leukocyte count of 1,480 mm -1 (with 78% neutrophilis), total proteins 0.65 g/dl, albumin of 0.25 g/dl. Serum/ascites albumin gradient (SAG) was 2.45 g/dl. The finding of a low albumin and a moderately high leukocyte count in the ascitic fluid supported the diagnosis of spontaneous peritonitis. Antibodies for hepatitis B surface antigen (anti-HBs) and HCV (Anti-HCV) were all found to be positive. Abdominal ultrasonography (US) revealed chronic parenchymal liver diseases, splenomegaly, and ascites. After ascitic fluid and urine specimens was taken for the culture, the patient was treated empirically with cefepime 2 · 1 g iv. The urine culture was sterile and the ascitic fluid culture was positive, showing a pure culture of A. urinae. On the third day of the therapy, the control paracentesis was made and we observed that the leukocyte count had decreased to 130 mm -1 . The patient's conditions had improved and the therapy was continued for 7 days. Case 2A 61-year-old female with stage IIIA multiple myeloma was admitted to our hospital with a 7-day history of high fever (39°C). The physical examination was unremarkable except that hepatomegaly was observed. The laboratory results as follows: leukocyte count 4,660 mm -1 , hemoglobin level 7.8 g/dl, hematocrit 21%, and CRP 261 mg/l. Laboratory findings including electrolytes, glucose, liver, renal, and thyroid function tests were reported as normal. After blood and urine specimens were ta...

Background/Aim. To identify the etiological role of Helicobacter pylori (Hp) and nonsteroidal anti-inflammatory drugs (NSAIDs) in endoscopically diagnosed duodenal ulcers (DUs). Methods. Patients undergoing esophagogastroduodenoscopy in two major hospitals in Antalya and Adiyaman were included in this study and assigned as duodenal ulcer (n = 152; median age: 41.0 (16–71) years; 58.6% males) or control group (n = 70; median age: 41.0 (18–68) years; 57.1% males). Patient demographics, risk factors, and NSAID/acetylsalicylic acid (ASA) use were recorded. Results. HP was more commonly located in the corpus (75.0 versus 50.0%; odds ratio [OR] = 3.00; 95% confidence interval [CI]: 1.66–5.44; P < 0.001), incisura (75.7 versus 60.0%; OR = 2.07; 95% CI: 1.13–3.79; P = 0.017), and antrum (80.3 versus 60.0%; OR = 2.71; 95% CI: 1.45–5.05; P = 0.001) among DU patients than controls. Hp positivity was 84.9% while Hp was negative in 15.1% of patients including those accompanied with NSAID and/or ASA use (9.2%), and those were negative for all three etiological factors (5.9%). Conclusion. Our findings indicate the substantial role of Hp in the pathogenesis of DU disease as identified in 84.9% of DU patients compatible with the background prevalence of 61.4% among age-matched control subjects. Hp was the single causative factor in 44.1% of our patients, while NSAID/ASA exposure was in 9.2%.

Amaç: ‹skemi-reperfüzyon hasar› klinik pratikte karaci¤er nakli ile ilgili ciddi bir komplikasyon olmaya devam etmektedir. Bu çal›fl-ma, s›çanlarda deneysel hepatik iskemi-reperfüzyon hasar› üzerine L-karnitinin etkisini de¤erlendirmek için tasarlanm›flt›r. Gereç ve Yöntem: Toplam 45 erkek Grup 3'den (267.6(56.6 )U/L); ortalama (SD) alanin aminotransferaz de¤erleri Grup 2 (257(97.7)U/L) için Grup 1 (37.2(6.6)U/L) ve Grup 3'den (118.1(46.7)U/L); ortalama (SD) laktat dehidrogenaz de¤erleri Grup 2 (2943.8(166.1)U/L) için Grup 1 (1496.5(274.8)U/L) ve Grup 3'den (2185.3(258.7)U/L); ortalama (SD) doku malondialdehit düzey-leri Grup 2 (54.3(2.8)nmol/gr) için Grup 1 (41.0(1.4)nmol/gr) ve Grup 3'den (42.1(3.8)Anahtar kelimeler: L-karnitin, hepatik iskemi-reperfüzyon hasar›, antioksidan, lipit peroksidasyonu Background/aims: Ischemia-reperfusion injury may occur during liver transplantation and remains a serious concern in clinical practice. This study was designed to study the potential benefit of L-carnitine on experimental warm hepatic ischemia-reperfusion injury in rats. Materials and Methods: Forty-five male Wistar Albino rats were divided into three groups; Group 1 sham-operation without ischemia-reperfusion (n=15); Group 2, ischemia-reperfusion (n=15); and Group 3, which was administered L-carnitine (200 mg/kg, intraperitoneal, for 4 days) prior to ischemia-reperfusion (n=15

Şahintürk Y, Taşkoparan M, Uyar S, et. al. The current status in gastric cancer: localization, pathology, and age. Endoscopy Gastrointestinal 2016;24:61-64. kanserlerin yaklaşık %50'sinin kardiya ya da fundus kaynaklı olduğu bildirilmiştir (3).Çalışmalarda PGK'nın distal gastrik kansere (DGK) göre daha kötü prognoza sahip olduğu gösterilmiş ve bu durum PGK'nin farklı klinik ve biyolojik davranış göstermesine bağlanmıştır (4). Özellikle obezitenin (3,5) ve sigara kullanımının (6,7) GİRİŞMide kanseri kanser nedenli ölümler arasında ikinci sıradadır. Gelişmiş ülkelerde son yıllarda sıklığı azalma eğilimi gösterse de gelişmekte olan ülkelerde ve mide kanserinin endemik olduğu ülkelerde görülme sıklığı artmaktadır. Son 30 yılda yapılan bir çok çalışmada proksimal gastrik kanser (PGK) insidansında artış olduğu bildirilmiştir (1,2). Amerikan ulusal kanser verileri de bu durumu destekler niteliktedir ve gastrik Background and Aims: Gastric cancer is the second most common cancer-related cause of death throughout the world. It is reported that in recent years, proximal gastric cancer cases have increased, and distal gastric cancer cases have decreased in western countries. We searched for the newly-diagnosed gastric cancer cases between 2010 and 2015 in order to determine the localization, pathology, and age status of the patients. Materials and Methods: Gastric cancer cases diagnosed between 2010 and 2015 in the Antalya Training and Research Hospital and the Ankara Güven Hospital were retrospectively evaluated. A total of 203 patients were included in the study. The patients were divided into two groups according to the year of diagnosis, the first group being diagnosed between 2010 and 2013 and the second one, between 2013 and 2016. These two groups were compared according to the localization and pathology of the tumor and the age of the patients. Results: From the total, 126 (62.1%) patients were male, and 77 (37.9%) were female. There was no statistically significant difference between the mean age of the male and female patients (p > 0.05). A total of 203 patients were studied and 68 (33.5%) were diagnosed as having proximal and 135 (66.5%) as having distal gastric cancer.[Editor1][J2] Proximal gastric cancer cases were more frequent in the second group, but this was not statistically significant. The age and sex showed no difference according to the localization of the gastric cancer (p > 0.05). 154 (75%) adenocancer, 25 (12%) carcinoid tumor, 15 (8%) lymphoma, and 9 (5%) stromal tumor cases were detected. Carcinoid tumor cases were more frequent in the second group, but this was not statistically significant. The age and sex showed no difference according to the pathological type of the gastric cancer (p > 0.05). The rate of stomach cancer under the age of 45 constituted 13.5% of all of the patients. Conclusion: Gastric cancer is mostly seen in the corpus, then in the antrum, and least in the cardia. Our results are inconsistent with the recent studies showing a proximal gastric cancer dominancy, but we showed ...