COVID- 19 has created a lot of hazardous health issues worldwide. Research fraternity around the world is trying to find out vaccine or medicines against the virus. In this pandemic situation, there is a need for remedies to boost the immunity to fight against the virus. Ayurveda treatises have described several herbal drugs which are used as home remedies and are said to be effective against all microorganisms and effective in boosting immunity. Home remedies can be played a vital role as immunomodulant. Hence in this paper, an attempt is made to review such home remedies and identify its efficacy on various conditions. The relevant references were searched on the internet to find out the scientific data available on home remedies. Fumigation, Rasayan drugs, a decoction of herbal medicines found more useful. Tinospra cordifolia, Glycyrrhiza glabra, Ocimum sanctum, Withania somnifera, Curcuma longa are most decorated single herbal drugs used as home remedies for boosting the immunity. Considering the global disease burden caused by COVID-19, there is an urgent need to explore and widened the use of home remedies to fight against COVID-19 menace effectively.

The medicines prepared by using exudates of Commiphora mukul (Stocks) Hook. are described in Ayurveda under Guggula Kalpana which are among such valuable dosage forms. According to retrospective literary review, the combination of Kukkutnaki (Aspidium cicutarium Sw.) and purified Guggula(Commiphora mukul (Stocks) Hook.) was first mentioned in the book Chikitsa pradeep named as Kukkutnaki Guggula. Since last 3 decades, it was documented as an herbal drug which is used for cysts, goiter, tumors, tonsillitis, abscess, mansvaha strotas ailments, which are burning issues worldwide. Due to its observed clinical efficacy in Arbuda (~Cancer), the current in-vitro anticancer study was conducted with an aim to check its anticancer effect on human hepatoma cell line-HEPG2 of Liver; PC-3 and DU145 cancer cell lines of Prostate; Ovcar-3, A2780, SK-OV-3, PA-1 cancer cell lines of Ovary and ACHN renal cancer cell line of Kidney. The current in vitro study was conducted at ACTREC, Kharghar, Navi Mumbai. The selected cancer cell lines were procured from ATCC, USA and NCCS Pune. The Sulforhodamine B (SRB) Assay protocol was followed to observe the activity of the study drug. The positive control was Adriamycin in the study. The growth curve graphs were plotted and LC50, GI50, TGI values were calculated. Kukkutnakhi Guggula was found safe for oral administration, non- toxic at cellular level (LC50 values were > 160) and have moderate activity on HEPG2, Ovcar-3, DU145, ACHN cancer cell lines and had shown negligible activity on A2780, SK-OV-3, PA-1 and PC-3 cell lines. This work provides scope to study its effect on targeted cancers, specific in vivo scientific studies and human clinical trials for further researchers.

COVID-19 is an infectious pandemic disease caused by the virus called as SARS-CoV-2. It is the pathogens that primarily target the respiratory system of human beings. The most common symptoms at the beginning of COVID-19 illness are, cough, fever, muscle pain, diarrhoea, headache, and Acute Respiratory Distress Syndrome occurs in severe cases. The idea of Srotas, in all different appropriate meaning, is still related in the current situation and might give different visions if revisited. Hridaya (Heart) and Mahasrotas(Gastro-intestinal tract)  and are the origins  of Pranavahasrotas (respiratory system). In the view of the current review, the introductory classical text of Ayurveda like Charak Samhita and compilation textbooks, research publication and internet sources are also reviewed to explore the relation of Pranavaha srotas and COVID-19 disease.  In the diseases of Pranavaha srotas, similar symptoms are found as it is in connection with an organ like heart, lungs, brain and Gastro-intestinal tract. The treatment protocols for diseases of Pranvahahasrotas includes general Snehan Karma(Oleation) and Swedan Karma (Sudation) therapies, Vamana(emesis), Dhumapana (medicated smoking) therapy, Rasayan  therapy(Rejuvenation Therapy), treatment of Jwar(fever) and classical formulations like Kantakari ghrita, Shrungyadi Churna, Talisadi churna, Vasa Avaleha, Kanakasava, Shwasakuthar Rasa, Mahalaxmivilas rasa etc. recommended. So current review will be useful for research on treatment protocol mentioned for the management of diseases of Pranavaha srotas given COVID-19 and also as a reference for additional safety and efficacy studies; pharmaceutical manufacturing as well as standardization of classical formulations stated for the treating diseases of Pranavaha srotas.

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