The study involved measurement of medical, biological and antioxidant importance of toxoplasmosis and the effect of the causative agent, Toxoplasma gondii ,on the level of the biochemical parameters in the serum of 225 pregnant women infected with toxoplasmosis compared with225serum of women infected as control group. The criteria taken into consideration are: Glutathione (GSH) , Albumine (Alb) , Uric acid (UA) , Malondialdehyde (MDA) , Peroxinitrate (No).The Results showed: A significant increase (p≤0.01) in level of GSH, MDA and NO whereas Alb and U.A decreased, compared to control group. Interference between infection and pregnancy periods showed an significant increase (p≤0.01) in level of GSH during 1-3 months pregnancy period and MDA and non-significant increase in level of NO during 6-9 months pregnancy period. Alb and UA levels decreased, as significantly (p≤0.01) in serum of pregnant infected women.

Reregulation of biochemical profile of host as a result of host cells-pathogen interaction may involve in pathogenesis of toxoplasmosis disease. The biochemical parameters in the placenta of Toxoplasma-infected pregnant women and noninfected pregnant women (control group) were investigated The criteria taken into consideration are: Superoxide dismutase (SOD) , Peroxidase (Px) , Glutathione-Stransferase (GST) , Lactate dehydrogenase (LDH) , Aryl esterase (AE) , Acetylcholine esterase (AchE) , Vitamin A,C and E As well as placental electrolytes including: Sodium (Na +) , Potassium (K +) , Chloride (Cl-) , Calcium (Ca ++) , Selenium (Se) , Cupper (Cu) , Zinc (Zn) , Iron (Fe) , Magnesium (Mg) and Manganese (Mn). The results showed: a non-significant increase in the activity of SOD, GST, LDH and AchE during 6-9 months, and activity of AE during 1-3 months, were determined whereas the activity of Px was decreased in all periods of pregnancyA non-significant increase in the level of vitamin E and non-significant decrease in levels of vitamin A and C during pregnancy periods in placentae of infected pregnant Were observed.. A significant increase (p≤0.01) in levels of Na + and K + during 1-3 months and Ca ++ during 3-6 months, whereas the level of Cldecreased during pregnancy periods. A significant increase (p≤0.01) in levels of Seand Mg during 6-9 months and a non-significant increase in level of Cu during 1-3 months and 6-9 months, whereas the level of Zn, Fe and Mn significantly decreased in all periods of Pregnancy in placenta infected women.