A local drug delivery system for treatment of periodontal pockets by antibiotic is often used on patient with periodontitis. However, a well-known side effect of the long-term use of antibiotics is the increase in Also, the latter drug was evaluated clinically for use in a mouth rinse. The results suggest that Chinese traditional drugs Folium and Radix Strobilanthis inhibited the growth of periodontopathic bacteria and cariogenic bacteria in vitro. Furthermore, Radix Strobilanthis inhibited the proliferation of oral bacteria when used in a mouth rinse.