Worldwide, chronic kidney disease (CKD) is reported to occur in more than 10% of the general population (Fugl-Meyer, Nilsson,

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The definition of neuroacanthocytosis syndromes is used to describe a group of diseases, which is characterized by acanthocytosis and neurological abnormalities. Neuroacanthocytosis syndromes are progressive, degenerative and genetically heterogeneous diseases that generally begin at the 3rd or 4 th decade of life. Age at onset, clinical and laboratory findings, family history, neurological and systemic involvement, and treatment options differ according to the subtypes. The treatment of neuroacanthocytosis syndromes is totally symptomatic and pharmacotherapy and surgery are used. In the literature, half of the neuroacanthocytosis cases are accompanied by vague psychiatric symptoms as beginning signs or full-blown psychiatric symptoms during the course of the disease. In this case series, we present three patients who displayed different psychiatric aspects in a short period of 6 months and were diagnosed with neuroacanthocytosis after thorough investigations in our psychiatry clinic. Common features and differential characteristics of the cases are discussed in the light of relevant literature. (Archives of Neuropsychiatry 2010; 47: 356-9)

Bu çalışmada, yetişkin DEHB olgularıyla kontrol grubu arasında retina sinir lifi tabakası (RSLT) karşılaştırılmıştır. Yöntem: Çalışma grubu DSM 5 kriterlerine göre tanı almış DEHB olan yetişkinler, kontrol grubu ise herhangi bir psikiyatrik bozukluğu olmayan yaş ve cinsiyet uyumlu katılımcılardan oluşmuştur. DEHB olan 26 yetişkinin 52 gözüne ve 26 kontrolün 52 gözüne spektral alan optik koherens tomografi (OKT) yapılmıştır. Bulgular: DEHB olan 26 yetişkinin 52 gözünü ve 26 kontrolün 52 gözünü karşılaştırdık; Retina sinir lifi kalınlığı (RSLK), ganglion hücre kompleksi (GHK), santral makula kalınlığı(SMK), makula iç (MİH-ORT) ve dış halkanın (MDH-ORT) ortalama kalınlığı DEHB grubunda anlamlı derecede düşük olarak bulunmuştur. Sonuç: Bu, yetişkin DEHB'de RSLT kalınlığını inceleyen ilk çalışmadır. Bulgularımız, DEHB'de RSLT kalınlığının düşük olduğunu göstermektedir. DEHB'li yetişkinlerin retinalarında miyelinsiz aksonlar azalmıştır. SD-OKT ile yapılan nicel ve tekrarlanabilir ölçümler çocukergen DEHB vakalarında hastalığın seyrini ve ilerlemesini göstermek için bir biyobelirteç olarak kullanılabilir. Anahtar Sözcükler: DEHB, yetişkin, optik koherens tomografi, retina sinir lifi tabakası kalınlığı SUMMARY Retinal Scan with Optical Coherence Tomography in Adult Attention Deficit Hyperactivity DisorderObjective: In this study, the retinal nerve fiber layer (RNFL) thicknesses were compared between adult attention deficit hyperactivity disorder (ADHD) cases and healthy controls. Method:The study included adults diagnosed with ADHD based on the DSM-5 criteria and age and gender matched healthy controls. Spectral area optical coherence tomography (OCT) was performed on the 52 eyes of 26 participants with ADHD and the 52 eyes of the 26 healthy control individuals.Results: Comparing the data on the 52 eyes of 26 ADHD participants and the 52 eyes of 26 healthy control participants indicated that the central macular thickness (CMT) and the RNFL thicknesses, the ganglion cell complex (GCC), the mean inner macular ring (MIR-AVG) and the mean outer macular ring (MOR-AVG) thicknesses were significantly lower in the ADHD group. Conclusion:This is the first study in the literature on the RNFL thickness in adult ADHD patients. Our findings demonstrated that RNFL thickness is lower in ADHD cases as the unmyelinated axons are reduced in ADHD. Hence, the quantitative and reproducible nature of Spectral Domain-OCT thickness measurements can be used as biomarkers to monitor disease progression in ADHD cases.

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