This study was designed to impact the effect of fenugreek (Trigonella foenum-graecum), sesame (sesamum indicum), and domperidone on the mammary glands of pregnant white rats spices Rattus norvegicus at different concentrations. Fenugreek was used in an oral dose of 0.5 ml / day as oil, while sesame was used with a dose of 1 g / day as powder and domperidone was used as liquid as an oral dose of 2 mg / day . The results of the histological examination in the group that dosed the fenugreek showed an increase in the size of the lobules and alveoli, and the lumen was larger than the control group, as well as its branching. The cavities contain internal folds representing the branching of the vesicle wall and the increase of the secreted material in addition to containing an amount of fat in the form of fat droplet within the secretory materials in the lumen Alveoli. In the group dosed with sesame observed an increase in the size of lobules and alveolitis and their branching and increased secretory material compared with the control group was also found, but that was less than the other two test groups. In the domperidone group was found an increase in the size of lobules and alveoli and an increase in branching was observed. The secreted material inside the alveolar cavities also increased with an increase in lipid droplets within the secretory material compared with the control group and the other two experimental groups