The aim of this study was to detect the level of optimism and pessimism and its relation to the quality of life in patients with renal failure in the government and private hospitals in Irbid in light of the variables: gender, age, duration of disease and educational level of patients, the sample of the study consisted of (93) patients with kidney failure, who were randomly selected from the study population. The researchers used optimism and pessimism scale and the quality of life scales, their validity and reliability were verified. Results of the study showed that the means for optimism scale ranged between (3.602-3.075) with a medium degree, and the means for pessimism scale ranged between (4.086-3.118) with a high and medium degree, while the means for quality of life scale ranged between (4.054-2.957) with a high and medium degree. Results also showed the existence of a correlation between the level of optimism and the level of quality of life and this relationship is a moderate relationship, and a lack of correlation between level of optimism and level of pessimism and level of pessimism and quality of life. There are no statistically significant differences at the level of significance (0.05) in the patients' responses on the optimism, pessimism scales according to (gender, family income, medical insurance and origin).