Objective: To report a case of Churg-Strauss syndrome who had asthma and allergic rhinitis treated with montelukast. Clinical Presentation and Intervention: A nonsmoking 59-year-old woman presented with fever, hemoptysis and dyspnea. Past medical history included allergic rhinitis and asthma which were diagnosed 18 years ago. The asthma was treated successfully with inhaled salmeterol and beclamethasone. She also received montelukast (10 mg/day) for 3 years. Although her chest X-ray was normal a week earlier, she had widespread bilateral pulmonary infiltrates on admission. She had leukocytosis (12.5 × 109/l) with eosinophilia (15.6%). Her total IgE count was 550 U/ml. Testing for protoplasmic-staining antineutrophil cytoplasmic antibodies was positive. Bronchoalveolar lavage could not be performed due to bronchospasm and severe hypoxemia; however, mucosal biopsies were obtained, which revealed eosinophil leukocytes in the lumen and walls of small vessels. She was diagnosed to have Churg-Strauss syndrome and had remarkable clinical improvement on day 5 with high-dose of oral prednisolone (50 mg/day). Radiological improvement was detected at the end of the second week. Conclusion: This case shows the importance of being aware that leukotriene receptor antagonists could cause Churg-Strauss syndrome, in spite of the uncertainty about its mechanism.
Akut pulmoner emboli (PE) kardiyovasküler hastalıklar içinde üçüncü sıklıkta ölüme neden olan önemli bir hastalıktır. Prognoz tayininde çeşitli skorlamalar ve periferik kan belirteçleri tanımlanmış olsa da daha pratik ve kolay ulaşılabilecek belirteçlerin arayışı devam etmektedir. Bu çalışmanın amacı akut PE hastalarında tam kan sayımı parametreleri, nötrofillerin lenfositlere oranı (NLO) ve plateletlerin lenfositlere oranı (PLO) ile hastane ve uzun dönem mortalitesi arasındaki ilişkiyi araştırmaktır. Materyal veMetod: Çalışma retrospektif, gözlemsel bir çalışmadır. Haziran 2016-Haziran 2018 tarihleri arasında göğüs hastalıkları kliniğimizde PE tanısı ile yatışı olan ve tanısı doğrulanan 74 hasta çalışmaya dahil edildi. Hastaların demografik özellikleri, bazal tam kan sayımı, D-dimer (mg/L) ve C-reaktif protein (mg/L) değerleri kaydedildi. Hastane ve uzun dönem mortalitesi ile ilişkili faktörler araştırıldı. Bulgular: Çalışmaya dahil edilen 74 hastanın yaş ortalaması 65±18 (20-89) ve 36'sı erkek (%49) idi. Emboli lokalizasyonu hastaların %51'inde ana pulmoner arterdeydi ve sağ kalp yüklenme bulguları 8 (%10) hastada eşlik etmekteydi. NLO ortalaması hastanede ölen hastalarda 9,8±7,1 saptanırken taburcu edilenlerden anlamlı olarak daha yüksekti (NLO=5,3±4,8) (P=0,037). Yüksek NLO değerleri uzun dönem takiplerde mortalite ile ilişkili bulundu (P=0,047). Uzun dönem mortalitesi ile ilişkili diğer faktörler erkek cinsiyet (P=0,002), düşük hemoglobin (P=0,013) ve ileri yaş (P=0,023) olarak saptandı. Sonuç: Akut PE yakın takip gerektiren mortalitesi yüksek bir hastalıktır. Yüksek NLO değerleri kısa ve uzun dönem mortalite ile ilişkilidir ve yüksek riskli hastaları belirlemek için kullanılabilecek ucuz, basit ve kullanışlı bir parametredir Anahtar kelimeler: lenfosit; nötrofil; pulmoner emboli Is there Any Relationship Between Long-Term Mortality of Acute Pulmonary Embolism and Complete Blood Count Analysis? ABSTRACT Background: Acute pulmonary embolism (PE) is a challenging disease as the third most common cause of cardiovascular death. Despite various scoring systems and blood parameters, more simple and practical predictors are being investigated.The objective of this study is to investigate the relationship between the hospital and long-term mortality and complete blood count parameters, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with acute PE. Methods:The present study is a retrospective observational study. Between June 2016 and June 2018, patients hospitalised in our chest disease clinic with evident PE were included. Demographics, baseline complete blood count, D-dimer (mg/L) and C-reactive protein (mg/L) values were recorded. In-hospital mortality and long-term mortality were investigated and predictors of mortality were analyzed.Results: Of all the 74 patients, 36 (49%) were male and the mean age was 65±18 (20-89). Embolus was localised in the main pulmonary artery in 51%, right heart dysfunction was noted in 8 (10%) patients. Baseline NLR was significantly higher in ...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.