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isolation of The incorporation of a Pt-S bond in a well-defined complex prior to any administration may have considerable effects on this biology and the fact that Pt-S complexes are antitumor active may be relevant to the mechanisms of some of the above-mentioned effects. An interesting point to note here also is that albumin, the predominant agent responsible for tissue binding of Pt complexes, has been used (as protein BSA) as a template for the preparation of chiral sulfoxides.37 It is therefore axiomatic that chiral sulfoxide complexes will react differently with this enzyme. The chemical aspects of the biodistribution, tissue binding, and metabolism of platinum antitumor complexes are not as well understood as those of DNA binding, but it is clear that these properties may vary quite widely between, (35) Zwelling, L. A. Biological Consequences of Platinum-DNA Crosslinks in Mammalian Cells. In Platinum, Gold, and Other Metal Chemoth-

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