Background: The present study was carried out to correlate clinical diagnosis of new leprosy cases with that of histopathological diagnosis of skin biopsies stained with Haematoxylin and Eosin followed by Fite Faraco stain.Method: Skin biopsies of 70 newly diagnosed leprosy patients were fixed in 10% formalin and routine histopathological examination done followed by special stain (Fite Faraco) to evaluate the bacterial index.Results: From this study it was observed that, the commonest age group affected by leprosy was 31 to 50 years, males are twice more commonly affected than females (M:F = 1.9 : 1) and the most commonest clinically diagnosed spectrum was Tuberculoid leprosy (TT). The commonest histopathologically diagnosed spectrum was Indeterminate leprosy(IL). It was observed that there was complete agreement between clinical diagnosis and histopathological diagnosis in 62.85% cases and disagreement was observed in 37.15% cases. Conclusion:In case of confirmed discrepancy, the more advanced findings (ie. towards the lepromatous pole) should be given greater weightage and the case is to be classified and treated accordingly.

BACKGROUND: Breast cancer accounts for 14% of all cancers in Indian women, that can occur at any age. Cancer survival becomes more difcult in higher stages of tumour, hence in order to improve the survival of affected persons, early diagnosis of breast cancer is critical. METHODS: Retrospective study of 48 mastectomy specimens with relevant clinical details and respective H&E stained slides were reviewed. CONCLUSION: This review showed that occurrence of Invasive Breast Carcinoma(IBC) peaks in the age group of 41-50years (35.4% ) with right and left breast being affected equally in the ratio of R:L – 1 : 1. Most of the IBC (91.6%) were of No Special Type (NST), with 75% of tumours were of Histological Grade II. 58.3% of tumours were of tumour stage T along with lymph node involvement in equal number of cases.

Background: Breast carcinoma is the major cause of mortality and morbidity in Indian women. Though breast carcinoma arises from epithelial cells, stroma also plays a very important role in the pathogenesis of carcinoma breast which is assessed by the stromal marker CD 10.Aim: To study the stromal expression of CD 10 in carcinoma breast and find its relationship with other prognostic markers and study the role of stroma in pathogenesis of breast carcinoma.Materials and Methods: 50 cases of breast cancer were included in the study. H & E slides were retrieved, reviewed and IHC was done with a panel of markers which included ER, PR, HER2/neu and CD 10. Stromal expression of CD 10 in invasive breast carcinoma was noted and analysed in correlation with other prognostic markers.Results: Significances in the stromal CD 10 expression was calculated in regard to ER, PR & HER2/neu. Higher the tumour grade, more was the CD 10 stromal expression. Conclusion:As per the study, it is mandatory to include CD 10 stromal marker along with the panel of epithelial markers in invasive breast carcinoma. CD 10 contributes a potential target for development of novel therapies.

BACK GROUND: The incidence of gastric cancer is increasing worldwide, that presents with varied symptoms and signs. To diagnose gastric cancer in early stage we need to evaluate various clinical parameters and to grade the tumour we need to correlate with expression of P21 in tissue sample. METHODS: Clinical parameters like age, sex, symptoms & signs and tumour location of 50 patients were noted from the biopsy register and paraffin blocks with tumour of corresponding patients were evaluated for P21 expression by immunohistochemistry. CONCLUSION: In the present study, men were twice more commonly affected by gastric cancer than women. Most of the patients were aged above 50 years of age. P21 expression was found to be positive in most of the well differentiated grade and loss of P21 expression was noted in most of the poorly differentiated gastric adenocarcinoma.