Pyridoxine (vitamin B 6 , VB 6) was detected in pharmaceutical preparation and human urine samples by employing differential pulse voltammetry (DPV) at unmodified boron doped electrode. In Britton-Robinson buffer solution (BRBS) at pH 6 VB 6 provides well defined oxidation peak at around +1.05 V vs. Ag/AgCl (3M KCl). The influence of most of the interferents present in real samples, supporting electrolyte and DPV parameters were investigated. A VB 6 sensor with and linear range from 7 to 47 and a detection limit of 3.76 was obtain after optimization. Repeatability of the proposed procedure calculated after 7 measurements of 9 and 30 µM of VB 6 were 3.6 and 2.4 %, respectively. Proposed methodology was successfully applied for the determination of VB 6 in real samples, and from obtained results it can be concluded that proposed analytical procedure can be inexpensive alternative to the widely used separation methods.

No abstract

10 and 20 mg of N-Propyl-ajmalin-hydrogentartrate (N-PAB, Neo-Gilurytmal) were administered i.v. and orally respectively to healthy volunteers. In the study 14C-labelled N-PAB was used. The pharmacokinetics and the metabolic behaviour was examined. A fast and complete absorption of the compound could be observed. The bioavailability was 78%. The terminal plasma elimination half-life (beta-phase) was in the range of 4 to 6 hours. A total of 33% of the administered radioactivity was excreted via the kidney. 35 to 48% of the radioactivity found in urine was unchanged N-PAB. The excretion-kinetics of the three main metabolites as well as of the parent compound were determined. The possible presence of non-metabolizers is suggested.

No abstract

No abstract