It is noteworthy that 33.3% of the patients treated with olanzapine and 40.0% of the patients treated with quetiapine showed prolonged leukopenia. This finding is also consistent with the literature that declares higher numbers of cases about prolongation of clozapine-associated granulocytopenia for olanzapine and quetiapine than risperidone and amisulpride. After switching to another antipsychotic drug, close monitoring of white blood cell count on a daily basis for the first 2 weeks should be continued until white blood cell counts are stabilized. Quetiapine and olanzapine especially need attention after clozapine-associated granulocytopenia. Further studies with larger series and longer follow-up should be carried out.
A 25-year-old man patient was diagnosed with Behçet disease (BD) based on international study group criteria with findings of oral aphthous ulcers, genital ulcers, and panuveitis, and treatment with cyclosporine (200 mg/d) and azathioprine (3 mg/ kg per day). As the maintenance treatment, azathioprine (2 mg/ kg per day) was continued. Ten years after the diagnosis, he was admitted to our outpatient rheumatology clinic with complaints of nervousness, intolerance, desire to inflict harm on others, and paranoid symptoms, which started 1 month previously. His systemic and neurological examinations were normal. In the psychiatric examination, visual hallucinations and paranoid symptoms were detected. The evaluation of neuropsychological test battery consisting of Rey, Stroop, and Wisconsin testing demonstrated that the short-term memory function was normal while the long-term memory function and the ability of focusing were impaired. Erythrocyte sedimentation rate and C-reactive protein levels were 3 mm/h (normal, 0-20) and 3.2 mg/L (normal, 0-5), respectively. Cranial computed tomography (CT) was performed, and no pathological findings were observed. He was diagnosed with psychosis, and amisulpride 100 mg/d was prescribed by the department of psychiatry. To determine the etiology of psychosis, he underwent brain magnetic resonance imaging (MRI), which revealed suspicious right hippocampal sclerosis. As this finding was not diagnostic for neuro-Behçet disease (NBD), 18 F-FDG positron emission tomography (PET)/MRI was performed, which showed From the
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