Venlafaxine, which is often used for a number of psychiatric-related conditions such as the treatment of major depression, generalized anxiety disorder, social anxiety disorder and panic disorder, is generally a drug that is well tolerated and safe. The side effects of drugs can cause the treatment to prematurely terminate. Clinicians should prefer appropriate and low side-effects drugs to prevent this. This situation is also especially important for psychiatric patients. Prostatism, which impairs quality of life, is an important medical condition, with clinical and social implications. In the previous studies, prostatism was declared as a side effect of some antidepressant such as milnacipran, duloxetine and reboxetine. In our case, we discussed that venlafaxine-related prostatism developed in a male patient. As far as we know this is the first report of venlafaxine-induced prostatism.ARTICLE HISTORY

Drug-induced alopecia, characterized by non-scarring hair loss of scalp and body, is a rare side effect of psychotropic drugs. It has previously been reported with the different antidepressant medications, but has not been described with agomelatine. Agomelatine is an antidepressant with a novel mechanism of action and fewer side effects. Here, we report a 31-year-old male patient with diffuse hair loss induced by agomelatine use and improved by discontinuation the drug. Because antidepressant-induced hair loss is relatively rare, many clinicians may not pay attention for this side effect. As far as we know, this is the first published case report of alopecia associated with agomelatine. ARTICLE HISTORY

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Günümüzde depresyon tedavisinde SSRI olan ilaçlar düşük yan etkileri ve kolay tolere edilebilmelerinden dolayı ilk sırada tercih edilen güçlü ve etkili ilaçlardır. Sinaptik aralıkta serotonin miktarını arttırarak etki gösteren essitalopramın, yan etki profili SSRI sınıfındaki diğer ilaçlarla benzerdir. Nokturnal bruksizm, uyku sırasında dişlerin fonksiyonel olmayan şekilde sıkılması, istemsiz çene kilitlenmesi, diş gıcırdatma ve aşındırmayı içine alan bir motor bozukluktur. Nokturnal bruksizmin başlangıç mekanizması henüz tam anlaşılabilmiş değildir fakat nörokimyasal mekanizmalar üzerinde durulmaktadır. Serotonerjik aktivite artışı ile SSRI'ların nokturnal bruksizm oluşturabileceğini gösteren yayınlar mevcuttur. Bu yazımızda essitolapram 10 mg/gün kullanan hastada gelişen bruksizm ve dental fraktürün sunulması amaçlanmıştır.

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