The present study was undertaken to understand the realities of cancer patients' and their family members' distresses and inquiries, including medical/physical, emotional/spiritual and social/economic problems, from scientific viewpoints. The initial step of the study was to develop the classification category for these distresses and inquiries
A new synthetic method of conjugated enones by the use of carbanion-induced Favorskii-type rearrangement is described. The reaction of α,α′-dihalo ketones R1R2(X)CC(O)CH2X with sodiomalonates Na+ −CR3(CO2R4)2 in THF at 0°C—room temperature gave conjugated enones R1R2C=CHC(O)CR3(CO2R4)2 in 42–66% yields. The reaction can be also adaptable to the enolates of ethyl cyanoacetate or malononitrile to give the corresponding enones.
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