At the present scenario, the action of ensuing the philosophy of reducing energy consumption and saving it for longer period without drop off in performance is increased. On the other hand, global warming and ozone layer depletion become foremost challenges. These concerns are takes place in Thermal systems like refrigerator and air conditioning. To resolve the above challenges, the nano refrigerants are used in refrigeration, which has previously got the attention due to its distinctive properties such as thermal conductivity. They also have the potential to improve the heat transfer performance of refrigeration. This project interrogated on the performance of domestic refrigeration system using normal condenser and microchannel condenser with and without nanoparticles. The Cerium oxide and Zinc oxide nanoparticles in the size of about 20-30nm and 30-50nm respectively with R134a domestic refrigerant were used. The experimentation carried out using 2 gm ofCeO2and ZnO nanoparticles in three different ratios [0.5:1.5,1:1 and 1.5:0.5] with R134a refrigerant. Hereby, the result conquered that 33.3% increase in the Actual COP of domestic refrigeration system using normal condenser with 1:1 ratio of nanoparticles when compared with the refrigeration system using microchannel condenser with and without nanoparticles.