Although physical aggression in humans and other primates appears to be negatively associated with total serum cholesterol (TSC) concentrations, the relationship between other forms of aggression and TSC is less clear. A plurality of studies have reported a positive association, some have reported no association, and a minority have reported a negative association. Some authors have speculated that the variability in findings is attributable to inconsistencies in the definitions and measurement of what has often been termed "verbal" aggression. Buss and Perry have developed the Aggression Questionnaire, a theoretically-derived and empirically validated self-report measure of aggression that breaks aggression into subcomponents. One hundred and seventy-one college students and university personnel were recruited to participate in a cholesterol screening health initiative and then invited to participate in a study of mood and cholesterol. They completed a Demographic Questionnaire, and the Aggression Questionnaire. Regression analyses with age and Body Mass Index (BMI) as covariates revealed that anger, hostility, and verbal aggression significantly predicted TSC. Physical aggression did not. This finding suggests that non-physical forms of aggression may constitute a risk factor for coronary artery disease and one that may be worthy of targeting through behavioral interventions such as anger management training.