Background: Reproductive Tract infections (RTIs) in women is one among the wide spread health concerns. Untreated RTIs can cause adverse health and pregnancy outcomes, so there's a requirement for education and consultation thereon. Aim: This study aimed to assess effect of program on knowledge of early adulthood women about RTIs. Methods: Quasi-experimental research design was utilized in this study. It had been conducted at gynecological outpatient clinics of South Valley University's Hospital and General Qena Hospital. Sample included 380 women. Structured interview questionnaire was used and involved four sections (personal, obstetrics, gynecological and RTIs' knowledge). An academic program about RTIs was implemented on early adulthood women. Results: there is statistical significant difference between pre and post intervention regarding total knowledge about RTIs P-values are 0.001. Conclusion: There was an improvement within the total knowledge about RTIs after implementation program about RTIs. Recommendations: Planning and implementing program as a routine hospitalization with providing a booklet about RTIs and its preventive measures to scale back rate of RTIs among women.