Against the background of an increase in allergic diseases in humans, the issue of safety and bioavailability of meat products is very relevant today. The diversity of the biochemical composition of rabbit meat and the high percentage of its nutrients' digestibility by the human body determines the value of rabbit meat. In this regard, the study of the issues of increasing the rabbits' productivity is relevant. The aim of the work was to study the effect of the Bio-Mos probiotic on the productivity of Californian rabbits.The study was conducted on the basis of the FSBEI HE SAU of the Northern Trans-Urals and on the basis of the rabbit breeding complex of CJSC APPK "Roshchinsky" of the Tyumen region. The object was male rabbits at the age of 4 months. 2 groups were formed: control (regular diet), experimental (regular diet + Bio-Mos probiotic at a dose of 2 g per kg of granulated feed). Further, the stomach contents of rabbits were evaluated; biochemical analysis of muscle tissue samples, slaughter yield, organoleptic and microbiological indicators of meat were carried out. The studies revealed a positive effect on the digestibility of nutrients (fiber, copper, and zinc), as well as on the slaughter yield (an increase of 2.5%), an increase in the amount of protein (18.30± 0.19g/100g), fat (8.5±0.64g/100g) and the energy value of meat (647.90±6.59kJ/100 g). All this indicates an increase in productivity against the background of introducing Bio-Mos into the diet due to stabilization of the digestive system.