The biotechnological method of synthesis of ribavirin, vidarabin, and 6-azauridine by the use of immobilized recombinant enzymatic preparations of nucleoside phosphorylase was improved. The effect of ribavirin and its combinations with the other synthesized nucleosides on the reproduction of Vaccinia virus was studied using cultures of Vero cells. The combination of ribavirin and vidarabin was shown to provide an antiviral effect at lesser concentrations than when these compounds were taken separately. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 6; see also http://www.maik.ru.

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New results of combined therapy of herpetic infection in Vero cells infected with herpes simplex type I virus resistant to acyclovir (acycloguanosine, Zovirax) are presented. Paraaminobenzoic acid stimulates antiherpetic effects of acycloguanosine, 5-(2-bronaovinyl)-2'-deoxyuridine and adenine 9-13-D-arabinofuranoside. Para-aminobenzoic acid alone is incapable of suppressing type I herpes simplex virus reproduction in cell culture. Modified nucleosides combined with it exert a higher selective antiherpetic effect. Para-aminobenzoic acid is capable of inactivating herpes viruses in culture medium.