A case of a 66-year-old obese woman with type II diabetes mellitus and a 4 year history of virilism is presented. After removal of the ovaries the raised testosterone levels returned to normal and signs of virilism gradually receded. The histological finding of nodular hyperthecosis of the ovaries is discussed in relation to hyperinsulinaemia.

Objective: To investigate the relationship between the serum levels of the tumor markers squamous cell carcinoma antigen (SCC), carcinoma antigen (CA125) and carcinoembryonic antigen (CEA) and cytologic, colposcopic and histologic findings in women with cervical intraepithelial neoplasia (CIN). We also assessed whether a coefficient based on the three markers, namely the quotient (SCC CEA)/CA125, could detect women with histologically proven high-grade lesions missed by cytology or colposcopy. Materials and Methods: Ninety-eight women attending our Theodoros Agorastos, M. D.

A case of a 66-year-old obese woman with type II diabetes mellitus and a 4 year history of virilism is presented. After removal of the ovaries the raised testosterone levels returned to normal and signs of virilism gradually receded. The histological finding of nodular hyperthecosis of the ovaries is discussed in relation to hyperinsulinaemia.