No abstract

No abstract

Partial Least Square (PLS) and Artificial Neural Network (ANN) techniques were compared during development of an analytical method for quantitative determination of sulfamethoxazole (SMX) and trimethoprim (TMP) in Co-Trimoxazole®suspension. The procedure was based on Attenuated Total Reflectance Fourier Transform Infrared (ATR–FTIR) spectrometry. The 800–2500 cm−1spectral region was selected for quantitative analysis.R2and relative error of prediction (REP) in PLS technique were (0.989, 2.128) and (0.986, 1.381) for SMX and TMP, respectively. These statistical parameters were improved using the ANN models considering the complexity of the sample and the speediness and simplicity of the method.R2and RMSEC in modified method were (0.997, 1.064) and (0.997, 0.634) for SMX and TMP, respectively.

No abstract