The study involved 162 people, including 61 patients with type 1 diabetes mellitus (DM), 70 patients with slowly progressive autoimmune diabetes of adults and 31 patients with type 2 diabetes with the development of insulin dependence after more than 10 years since the disease onset. Based on a comparative analysis of fasting C-peptide levels in patients of observation groups the different degree of insulin secretion reduction was set. Thus in patients with type 1 diabetes mellitus severity of absolute insulin deficiency is not a determining factor of the variant of the disease (relatively stable or labile). In general, the definition of C-peptide in patients with diabetes is a reliable criterion by which we can judge the functional activity of β-cells, even in the appointment of insulin. In doubtful cases it is advisable to carry out the research of C-peptide in the dynamics of observation.

The problem of timely diagnosis and treatment of orphan diseases is today one of the leading in many countries of the world. The article considers the epidemiology of acromegaly, a rare disease that, in the absence of timely medical care, significantly reduces the life expectancy of patients. The review presents global data on the prevalence of disease and the establishment of registers of such patients and suggest ways to address the issue of timely diagnosis of acromegaly in Ukraine.

Автори гарантують повну відповідальність за все, що опубліковано в статті. Автори гарантують відсутність конфлікту інтересів і власної фінансової зацікавленості при виконанні роботи та написанні статті. Рукопис надійшов до редакції 18.09.2018.

The data of study to determine the emotional state of 84 patients with type 1 diabetes mellitus and their self-assessment of quality of life was given in the article. According to the study design all patients were divided into 2 groups depending on labile or relatively stable course of disease. The control group consisted of 22 healthy persons. Due to the application of generally accepted questionnaire use the absence of the ability adequate perception of their condition were determined in significant number of patients in both groups. This fact should be seen as a barrier to effective selfmanagement and, consequently, to achieve of satisfactory metabolic parameters. At the same time, the lack of «obsession» on the disease for a certain number of persons with type 1 diabetes mellitus indicates their perception of the disease as lifestyle.