Oral Squamous Cell Carcinoma (OSCC) ranks among the deadliest types of cancer worldwide. There are more than half a million diagnosed cases of squamous-cell carcinoma of the head and neck worldwide each year. The effect of alcohol consumption alone and synergistically with tobacco are etiological factors well documented in the literature. Although the relationship between vitiligo and malignancies was not well-established, various cases of malignant tumours were reported in association with vitiligo. When a patient presents with intra-oral lesions, it is critical to obtain a detailed history and physical examination. Early detection of cancer is a key factor for improved prognosis and increased patient survival rate. Dentists should evaluate lesions that do not heal within two weeks of removal of etiological grounds or irritation factors in terms of malignancy.